(E/Z)-BIX 02189

Name: (E/Z)-BIX 02189
SKU: A10151
Price: 175 CNY
Rating: 5 (2 reviews)

目录号: A10151

MEK 抑制剂

2 篇发表文献

BIX 02189 是一种选择性的双重 MEK5 和 ERK5（或 BMK1）激酶抑制剂，其 IC50 值分别为 MEK5 1.5 nM、ERK5 59 nM、TGFbR1 580 nM 以及其他密切相关激酶 >6200 nM。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥490.00	现货
10mg	¥840.00	现货
25mg	¥1,575.00	现货
50mg	¥2,730.00	现货
100mg	¥4,725.00	现货
200mg	¥6,615.00	现货
500mg	¥9,695.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用(E/Z)-BIX 02189 发表的2篇文献

Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418

Mitsunori Miyazaki, .et al. , FEBS Open Bio, 2017, Mar; 7(3): 424-433 PMID: 28286738

生物活性

Discription

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.

Targets

Target	Value

产品信息

目录号	A10151
分子式	C27H28N4O2
分子量	440.5
CAS号	1094614-85-3
SMILES	CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 56 mg/mL (127.11 mM)
	Water	Insoluble
	Ethanol	75 mg/mL (170.24 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.7 mL	113.51 mL	227.01 mL
0.5 mM	4.54 mL	22.7 mL	45.4 mL
1 mM	2.27 mL	11.35 mL	22.7 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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