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BIX02188

MEK5 抑制剂

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产品目录号: A10150

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BIX02188 5mg A10150-5
¥ 900.00
BIX02188 10mg A10150-10
¥ 1,600.00
BIX02188 50mg A10150-50
¥ 4,500.00
BIX02188 100mg A10150-100
¥ 7,500.00
BIX02188 10mM * 1mL in DMSO A10150-10mM-D
¥ 1,360.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BIX02188 is a potent and selective inhibitor of MEK5.

BIX02188

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Chemical Information

目录号 A10150
Mechanism of action Inhibitor
分子量 426.5
化学分子式 C26H26N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1094614-84-2
Synonyms BIX-02188
SMILES code CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4
化学名称 (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide

生物活性

Description
BIX02188 is a potent and selective inhibitor of MEK5.
Targets
Target Value
MEK5IC50: 4.3nM
ERK5IC50: 810nM
TGFβR1IC50: 1.8μM
MEK1IC50: >6.3μM
MEK2IC50: >6.3μM
ERK1IC50: >6.3μM
JNK2IC50: >6.3μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM

溶解性

Solubility (25°C) * In vitro DMSO 43 mg/mL (104.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (7.27 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.45 mL 117.23 mL 234.47mL
0.5 mM 4.69 mL 23.45 mL 46.89 mL
1 mM 2.34 mL 11.72 mL 23.45 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

*The above data is based on the productmolecular weight 426.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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