Bleselumab (ASKP 1240) is a humanized monoclonal antibody targeting CD40 with a high affinity of approximately 0.24 nM. By selectively binding to CD40, Bleselumab effectively blocks the interaction between CD40 and its ligand CD40L, a crucial pathway in immune response modulation. This inhibition is particularly relevant in preventing organ transplant rejection, making Bleselumab a significant tool in transplant immunology research.
Bleselumab (ASKP 1240) is a humanized monoclonal antibody targeting CD40 with a high affinity of approximately 0.24 nM. By selectively binding to CD40, Bleselumab effectively blocks the interaction between CD40 and its ligand CD40L, a crucial pathway in immune response modulation. This inhibition is particularly relevant in preventing organ transplant rejection, making Bleselumab a significant tool in transplant immunology research.
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