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BMS-265246

CDK 抑制剂

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产品目录号: A11154

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BMS-265246 5mg A11154-5
¥ 1,800.00
BMS-265246 10mg A11154-10
¥ 3,000.00
BMS-265246 50mg A11154-50
¥ 8,000.00
BMS-265246 100mg A11154-100
¥ 14,000.00
BMS-265246 10mM * 1mL in DMSO A11154-10mM-D
¥ 1,970.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.

BMS-265246

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Chemical Information

目录号 A11154
Mechanism of action Inhibitor
分子量 345.3
化学分子式 C18H17F2N3O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 582315-72-8
Synonyms BMS265246
SMILES code CCCCOC1=C2C=NNC2=NC=C1C(=O)C3=C(C=C(C=C3F)C)F
化学名称 (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone

生物活性

Description
BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.
Targets
CDK1/CyclinB (Cell-free assay) CDK2/CyclinE (Cell-free assay) CDK4/CyclinD (Cell-free assay)
6 nM9 nM230 nM

溶解性

Solubility (25°C) * In vitro DMSO 20 mg/mL (57.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.96 mL 144.8 mL 289.6mL
0.5 mM 5.79 mL 28.96 mL 57.92 mL
1 mM 2.9 mL 14.48 mL 28.96 mL
5 mM 0.58 mL 2.9 mL 5.79 mL

*The above data is based on the productmolecular weight 345.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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