BMS 299897

目录号: A12444

γ-secretase inhibitor

BMS 299897

BMS 299897 Chemical Structure

CAS NO. 290315-45-6

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.

库存: 现货

规格 价格 数量
10 mg
¥ 1,100.00
25 mg
¥ 2,200.00
50 mg
¥ 3,560.00
100 mg
¥ 6,800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.53 mL 97.67 mL 195.34 mL
0.5 mM 3.91 mL 19.53 mL 39.07 mL
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL

*The above data is based on the productmolecular weight 511.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A12444
MECHANISM OF ACTION Inhibitor
M. Wt 511.94
Formula C24H21ClF3NO4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 290315-45-6
Synonyms BMS 299897
SMILES C[C@H](C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

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