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BMS-536924

IGF-1R 抑制剂

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产品目录号: A11054

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BMS-536924 5mg A11054-5
¥ 1,200.00
BMS-536924 10mg A11054-10
¥ 2,000.00
BMS-536924 50mg A11054-50
¥ 5,800.00
BMS-536924 100mg A11054-100
¥ 8,800.00
BMS-536924 10mM * 1mL in DMSO A11054-10mM-D
¥ 1,740.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.

BMS-536924

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 BMS-536924 发表的文献 (1)
  • Qiao Zhou, .et al. BMS-536924, an ATP-competitive IGF-1R/IR inhibitor, decreases viability and migration of temozolomide-resistant glioma cells in vitro and suppresses tumor growth in vivo, Onco Targets Ther., 2015, 8: 689每697 PMID: 25897243

Chemical Information

目录号 A11054
Mechanism of action Inhibitor
分子量 480.0
化学分子式 C25H26ClN5O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 468740-43-4
Synonyms BMS536924
SMILES code CC1=CC(=CC2=C1N/C(=C/3\C(=CC=NC3=O)NC[C@H](C4=CC(=CC=C4)Cl)O)/N2)N5CCOCC5
化学名称 (R)-4-(3-(3-chlorophenyl)-3-hydroxypropyl)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one

生物活性

Description
BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.
Targets
Target Value
Insulin ReceptorIC50: 73nM
IGF-1RIC50: 100nM
FAKIC50: 150nM
MEKIC50: 182nM
LCKIC50: 341nM
CDK2/CyclinEIC50: >1μM
VEGFR2IC50: 1.4μM
EGFIC50: 1.6μM
MetIC50: 4.87μM
MAPK2IC50: ~5μM
MAPK1IC50: >5μM
Akt1IC50: >5μM
PDGFRIC50: >5μM
HER2IC50: 17.1μM

溶解性

Solubility (25°C) * In vitro DMSO 96 mg/mL (200.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.83 mL 104.17 mL 208.33mL
0.5 mM 4.17 mL 20.83 mL 41.67 mL
1 mM 2.08 mL 10.42 mL 20.83 mL
5 mM 0.42 mL 2.08 mL 4.17 mL

*The above data is based on the productmolecular weight 480.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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