BMS-708163 (Avagacestat)

Name: BMS-708163 (Avagacestat)
SKU: A10157

目录号: A10157

Gamma-secretase 抑制剂

BMS-708163 (Avagacestat) Chemical Structure

CAS NO. 1146699-66-2

BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。

库存：现货

规格	价格	数量
5 mg	￥ 1,100.00
10 mg	￥ 2,000.00
50 mg	￥ 6,800.00
100 mg	￥ 11,800.00
10mM * 1mL in DMSO	￥ 1,740.00

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生物活性

BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。

靶点信息

γ secretase(Aβ42)	γ secretase(Aβ40)
0.27 nM	0.3 nM

溶解度 *

In vitro	DMSO	90 mg/mL (172.78 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.2 mL	96.01 mL	192.01 mL
0.5 mM	3.84 mL	19.2 mL	38.4 mL
1 mM	1.92 mL	9.6 mL	19.2 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

*The above data is based on the productmolecular weight 520.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10157
作用机制	Inhibitor (抑制剂)
M. Wt	520.8
Formula	C20H17ClF4N4O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1146699-66-2
Synonyms	BMS708163
SMILES	C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[C@H](CCC(F)(F)F)C(=O)N)Cl