BMS-708163 (Avagacestat)

目录号: A10157

Gamma-secretase inhibitor

BMS-708163 (Avagacestat) Chemical Structure

CAS NO. 1146699-66-2

BMS-708163 is an oral gamma secretase inhibitor designed for selective
inhibition of amyloid beta synthesis.

库存: 现货

规格 价格 数量
5 mg
¥ 1,100.00
10 mg
¥ 2,000.00
50 mg
¥ 6,800.00
100 mg
¥ 11,800.00
10mM * 1mL in DMSO
¥ 1,740.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
Targets
γ secretase(Aβ42) γ secretase(Aβ40)
0.27 nM0.3 nM
In vitro DMSO 104 mg/mL (199.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.2 mL 96.01 mL 192.01 mL
0.5 mM 3.84 mL 19.2 mL 38.4 mL
1 mM 1.92 mL 9.6 mL 19.2 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 520.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10157
MECHANISM OF ACTION Inhibitor
M. Wt 520.8
Formula C20H17ClF4N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1146699-66-2
Synonyms BMS708163
SMILES C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)[C@H](CCC(F)(F)F)C(=O)N)Cl

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