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BMS-754807

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IGF-1R 抑制剂

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产品目录号: A11059

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BMS-754807 5mg A11059-5
¥ 600.00
BMS-754807 10mg A11059-10
¥ 1,000.00
BMS-754807 50mg A11059-50
¥ 3,500.00
BMS-754807 100mg A11059-100
¥ 6,000.00
BMS-754807 10mM * 1mL in DMSO A11059-10mM-D
¥ 650.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.

BMS-754807

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 BMS-754807 发表的文献 (1)
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961

Chemical Information

目录号 A11059
Mechanism of action Inhibitor
分子量 461.5
化学分子式 C23H24FN9O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1001350-96-4
Synonyms BMS754807, BMS 754807
SMILES code C[C@]1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F
化学名称 (2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-2-pyrrolidinecarboxamide

生物活性

Description
BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.
Targets
Target Value
Insulin ReceptorIC50: 1.7nM
IGF-1RIC50: 1.8nM
TrkBIC50: 4.1nM
MetIC50: 5.6nM
TrkAIC50: 7.4nM
AuroraAIC50: 9nM
AuroraBIC50: 25nM
RONIC50: 44nM
FLT3IC50: 170nM
JAK2IC50: 347nM
GSK-3βIC50: 785nM
CDK2EIC50: 795nM
MK2IC50: 919nM
LCKIC50: 1.218μM
SrcIC50: 1.527μM
PKAIC50: 1.605μM
PKCαIC50: 2.53μM
BTKIC50: 3.797μM
CSKIC50: 5μM
PKCδIC50: 12μM
PKCζIC50: >50μM
PKCιIC50: >50μM
p38αIC50: >50μM
p38βIC50: >50μM
HER1IC50: >50μM
IKK1IC50: >50μM
IKK2IC50: >50μM

溶解性

Solubility (25°C) * In vitro DMSO 92 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol 92 mg/mL (199.35 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.67 mL 108.34 mL 216.68mL
0.5 mM 4.33 mL 21.67 mL 43.34 mL
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL

*The above data is based on the productmolecular weight 461.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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