BMS-754807

目录号: A11059

IGF-1R 抑制剂

BMS-754807

BMS-754807 Chemical Structure

CAS NO. 1001350-96-4

BMS-754807是一种有效的,口服活性生长因子1受体/胰岛素受体家族靶向的激酶抑制剂。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 3,500.00
100 mg
¥ 6,000.00
10mM * 1mL in DMSO
¥ 650.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

BMS-754807是一种有效的,口服活性生长因子1受体/胰岛素受体家族靶向的激酶抑制剂。
Targets
Target Value
Insulin ReceptorIC50: 1.7nM
IGF-1RIC50: 1.8nM
TrkBIC50: 4.1nM
MetIC50: 5.6nM
TrkAIC50: 7.4nM
AuroraAIC50: 9nM
AuroraBIC50: 25nM
RONIC50: 44nM
FLT3IC50: 170nM
JAK2IC50: 347nM
GSK-3βIC50: 785nM
CDK2EIC50: 795nM
MK2IC50: 919nM
LCKIC50: 1.218μM
SrcIC50: 1.527μM
PKAIC50: 1.605μM
PKCαIC50: 2.53μM
BTKIC50: 3.797μM
CSKIC50: 5μM
PKCδIC50: 12μM
PKCζIC50: >50μM
PKCιIC50: >50μM
p38αIC50: >50μM
p38βIC50: >50μM
HER1IC50: >50μM
IKK1IC50: >50μM
IKK2IC50: >50μM
In vitro (25°C) DMSO 86 mg/mL (186.35 mM)
Water Insoluble
Ethanol 86 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.67 mL 108.34 mL 216.68 mL
0.5 mM 4.33 mL 21.67 mL 43.34 mL
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL

*The above data is based on the productmolecular weight 461.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11059
作用机制 Inhibitor (抑制剂)
M. Wt 461.5
Formula C23H24FN9O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1001350-96-4
Synonyms BMS754807, BMS 754807
SMILES C[C@]1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F

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