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BMS-911543

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JAK 抑制剂

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产品目录号： A11241

库存状态：中国现货中国现货

产品名 目录号 价格 数量
BMS-911543 5mg A11241-5
￥ 1,000.00
BMS-911543 10mg A11241-10
￥ 1,800.00
BMS-911543 25mg A11241-25
￥ 3,800.00
BMS-911543 50mg A11241-50
￥ 7,000.00

产品仅用于研究，不针对患者销售，望谅解.

产品简介

BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity.

BMS-911543

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Chemical Information

目录号 A11241
Mechanism of action Inhibitor
分子量 432.52
化学分子式 C23H28N8O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1271022-90-2
Synonyms BMS911543, BMS 911543
SMILES code CCN1C(=CC2=C3C(=C(N=C21)NC4=NN(C(=C4)C)C)N=CN3C)C(=O)N(C5CC5)C6CC6
化学名称 N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

生物活性

Description
 BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity.
Targets
JAK2 SET-2 TYK2 JAK3 JAK1
1.1 nM60 nM66 nM75 nM360 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.12 mL 115.6 mL 231.2mL
0.5 mM 4.62 mL 23.12 mL 46.24 mL
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

*The above data is based on the productmolecular weight 432.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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