BMS303141
目录号: A13807
ATP-citrate lyase 抑制剂
BMS303141 是一种强效的 ATP 柠檬酸裂解酶 (ACL) 抑制剂。BMS303141 在 HepG2 细胞中抑制脂质合成，其 IC50 为 8 μM，并在小鼠高脂血症模型中降低血浆甘油三酯水平。
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生物活性
| Discription | BMS303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model. | |||||
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| Cell Research |
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产品信息
| 目录号 | A13807 |
|---|---|
| 分子式 | C19H15Cl2NO4S |
| 分子量 | 424.3 |
| CAS号 | 943962-47-8 |
| SMILES | COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC(=CC(=C3O)Cl)Cl |
| 其他名称 | BMS 303141, BMS-303141 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 73 mg/mL (172.04 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.57 mL | 117.84 mL | 235.68 mL |
| 0.5 mM | 4.71 mL | 23.57 mL | 47.14 mL |
| 1 mM | 2.36 mL | 11.78 mL | 23.57 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 943962-47-8 | 943962-47-8 供应商 | 943962-47-8 花费 | 943962-47-8 生产商 | 订购 943962-47-8 | 943962-47-8 代理商