Borussertib
目录号: A13364
Akt 抑制剂
Borussertib 是一种共价-异构的首创类 Akt 蛋白激酶 抑制剂,对 Aktwt 的 IC50 为 0.8 nM,Ki 为 2.2 nM。
Discription | Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. |
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目录号 | A13364 |
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分子式 | C36H32N6O3 |
分子量 | 596.68 |
CAS号 | 1800070-77-2 |
SMILES | C=CC(NC1=CC=C(N2)C(N(C3CCN(CC4=CC=C(C5=NC6=C(C(NC=C6)=O)C=C5C7=CC=CC=C7)C=C4)CC3)C2=O)=C1)=O |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 95 mg/mL (159.21 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 16.76 mL | 83.8 mL | 167.59 mL |
0.5 mM | 3.35 mL | 16.76 mL | 33.52 mL |
1 mM | 1.68 mL | 8.38 mL | 16.76 mL |
5 mM | 0.34 mL | 1.68 mL | 3.35 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2