Bosentan Hydrate

Name: Bosentan Hydrate
SKU: A14944

目录号: A14944

ET-A and ET-B 拮抗剂

Bosentan Hydrate Chemical Structure

CAS NO. 157212-55-0

Bosentan Hydrate是ET-A和ET-B的内皮素（ET）受体拮抗剂，Ki分别为4.7 nM和95 nM。

库存：现货

规格	价格	数量
50 mg	￥ 600.00
100 mg	￥ 1,000.00
500 mg	￥ 3,000.00

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生物活性

Bosentan Hydrate是ET-A和ET-B的内皮素（ET）受体拮抗剂，Ki分别为4.7 nM和95 nM。

溶解度 *

In vitro (25°C)	DMSO	92 mg/mL (161.51 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (3.51 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.56 mL	87.78 mL	175.55 mL
0.5 mM	3.51 mL	17.56 mL	35.11 mL
1 mM	1.76 mL	8.78 mL	17.56 mL
5 mM	0.35 mL	1.76 mL	3.51 mL

*The above data is based on the productmolecular weight 569.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14944
作用机制	Antagonist (拮抗剂)
M. Wt	569.63
Formula	C27H29N5O6S.H2O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	157212-55-0
Synonyms	Ro 47-0203
SMILES	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC.O