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Brigatinib (AP26113)

ALK 抑制剂

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产品目录号: A13450


产品名 目录号 价格 数量
Brigatinib 5mg A13450-5
¥ 1,100.00
Brigatinib 10mg A13450-10
¥ 1,900.00
Brigatinib 25mg A13450-25
¥ 4,000.00



Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.

Brigatinib (AP26113)




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Chemical Information

目录号 A13450
Mechanism of action Inhibitor
分子量 584.09
化学分子式 C29H39ClN7O2P
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1197953-54-0
Synonyms AP-26113, AP 26113, AP26113
化学名称 5-chloro-4-N-(2-dimethylphosphorylphenyl)-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidine-2,4-diamine


Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.12 mL 85.6 mL 171.21mL
0.5 mM 3.42 mL 17.12 mL 34.24 mL
1 mM 1.71 mL 8.56 mL 17.12 mL
5 mM 0.34 mL 1.71 mL 3.42 mL

*The above data is based on the productmolecular weight 584.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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