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Brivanib (BMS-540215)


VEGFR-2 抑制剂

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产品目录号: A10254


产品名 目录号 价格 数量
Brivanib 5mg A10254-5
¥ 900.00
Brivanib 10mg A10254-10
¥ 1,600.00
Brivanib 50mg A10254-50
¥ 4,500.00
Brivanib 200mg A10254-200
¥ 12,000.00
Brivanib (BMS-540215) 10mM * 1mL in DMSO A10254-10mM-D
¥ 1,260.00



Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM.

Brivanib (BMS-540215)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Brivanib (BMS-540215) 发表的文献 (1)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168

Chemical Information

目录号 A10254
Mechanism of action Inhibitor
分子量 370.4
化学分子式 C19H19FN4O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 649735-46-6
Synonyms BMS540215
SMILES code CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)O)C
化学名称 (R)-1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-ol


Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM.
Target Value
VEGFR2IC50: 25nM
Flk1IC50: 89nM
FGFR1IC50: 148nM
VEGFR1IC50: 380nM
EGFRIC50: >1.9μM
LCKIC50: >2.5μM
PDGFRβIC50: >6μM
PKCαIC50: >25μM
JAK3IC50: >50μM


Solubility (25°C)* In vitro DMSO 74 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (8.09 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27 mL 134.99 mL 269.98mL
0.5 mM 5.4 mL 27 mL 54 mL
1 mM 2.7 mL 13.5 mL 27 mL
5 mM 0.54 mL 2.7 mL 5.4 mL

*The above data is based on the productmolecular weight 370.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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