Brontictuzumab (OMP 52M51) is a monoclonal antibody designed to target and inhibit the Notch1 signaling pathway. This antibody specifically binds to the negative regulatory region of Notch1, a critical component in cell differentiation, proliferation, and apoptotic processes. By inhibiting this pathway, Brontictuzumab effectively impedes tumor cell proliferation, making it a valuable tool in the study of hematological malignancies such as leukemia and lymphoma. Its selective binding affinity and inhibitory action on Notch1 provide a focused approach for researchers investigating the pathological roles of Notch1 signaling in cancer.
Brontictuzumab (OMP 52M51) is a monoclonal antibody designed to target and inhibit the Notch1 signaling pathway. This antibody specifically binds to the negative regulatory region of Notch1, a critical component in cell differentiation, proliferation, and apoptotic processes. By inhibiting this pathway, Brontictuzumab effectively impedes tumor cell proliferation, making it a valuable tool in the study of hematological malignancies such as leukemia and lymphoma. Its selective binding affinity and inhibitory action on Notch1 provide a focused approach for researchers investigating the pathological roles of Notch1 signaling in cancer.
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