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BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.59 mL | 102.97 mL | 205.93 mL |
| 0.5 mM | 4.12 mL | 20.59 mL | 41.19 mL |
| 1 mM | 2.06 mL | 10.3 mL | 20.59 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19465 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 485.6 |
| Formula | C24H31N5O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2286419-03-0 |
| Synonyms | BSc 5371, BSc-5371 |
| SMILES | O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(NS(=O)(C=C)=O)C=C3)=O)=C1C)NCCN(CC)CC |
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