BX-795

目录号: A11148

PDK-1 inhibitor

BX-795 Chemical Structure

CAS NO. 702675-74-9

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.

库存: 现货

规格 价格 数量
10 mg
¥ 1,200.00
25 mg
¥ 2,500.00
50 mg
¥ 4,200.00
100 mg
¥ 8,000.00
10mM * 1mL in DMSO
¥ 1,300.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
Targets
Target Value
TBK1/IKK?
PDK-1IC50: 6nM
c-KitIC50: 320nM
CDK2/CyclinEIC50: 430nM
Chk1IC50: 510nM
GSK-3βIC50: 620nM
PKAIC50: 840nM
KDRIC50: 1.1μM
T-FynIC50: 6.4μM
PKCIC50: 9.3μM
EGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
In vitro (25°C) DMSO 100 mg/mL (169.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.91 mL 84.53 mL 169.06 mL
0.5 mM 3.38 mL 16.91 mL 33.81 mL
1 mM 1.69 mL 8.45 mL 16.91 mL
5 mM 0.34 mL 1.69 mL 3.38 mL

*The above data is based on the productmolecular weight 591.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11148
MECHANISM OF ACTION Inhibitor
M. Wt 591.5
Formula C23H26IN7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 702675-74-9
Synonyms BX795
SMILES C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

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