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BX-795

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PDK-1 抑制剂

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产品目录号: A11148

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BX-795 10mg A11148-10
¥ 1,200.00
BX-795 25mg A11148-25
¥ 2,500.00
BX-795 50mg A11148-50
¥ 4,200.00
BX-795 100mg A11148-100
¥ 8,000.00
BX-795 10mM * 1mL in DMSO A11148-10mM-D
¥ 1,300.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.

BX-795

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 BX-795 发表的文献 (1)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168

Chemical Information

目录号 A11148
Mechanism of action Inhibitor
分子量 591.5
化学分子式 C23H26IN7O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 702675-74-9
Synonyms BX795
SMILES code C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I
化学名称 N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

生物活性

Description
BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
Targets
Target Value
TBK1/IKK?
PDK-1IC50: 6nM
c-KitIC50: 320nM
CDK2/CyclinEIC50: 430nM
Chk1IC50: 510nM
GSK-3βIC50: 620nM
PKAIC50: 840nM
KDRIC50: 1.1μM
T-FynIC50: 6.4μM
PKCIC50: 9.3μM
EGFRIC50: >10μM
Insulin ReceptorIC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (169.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.91 mL 84.53 mL 169.06mL
0.5 mM 3.38 mL 16.91 mL 33.81 mL
1 mM 1.69 mL 8.45 mL 16.91 mL
5 mM 0.34 mL 1.69 mL 3.38 mL

*The above data is based on the productmolecular weight 591.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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