BX-795

Name: BX-795
SKU: A11148

目录号: A11148

PDK-1 抑制剂

Product Citations (1)

BX-795 Chemical Structure

CAS NO. 702675-74-9

BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。

库存：现货

规格	价格	数量
10 mg	￥ 1,200.00
25 mg	￥ 2,500.00
50 mg	￥ 4,200.00
100 mg	￥ 8,000.00
10mM * 1mL in DMSO	￥ 1,300.00

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。

Targets

Target	Value
TBK1/IKK?
PDK-1	IC50: 6nM
c-Kit	IC50: 320nM
CDK2/CyclinE	IC50: 430nM
Chk1	IC50: 510nM
GSK-3β	IC50: 620nM
PKA	IC50: 840nM
KDR	IC50: 1.1μM
T-Fyn	IC50: 6.4μM
PKC	IC50: 9.3μM
EGFR	IC50: >10μM
Insulin Receptor	IC50: >10μM

溶解度 *

In vitro (25°C)	DMSO	88 mg/mL (148.78 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG +2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.91 mL	84.53 mL	169.06 mL
0.5 mM	3.38 mL	16.91 mL	33.81 mL
1 mM	1.69 mL	8.45 mL	16.91 mL
5 mM	0.34 mL	1.69 mL	3.38 mL

*The above data is based on the productmolecular weight 591.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11148
作用机制	Inhibitor (抑制剂)
M. Wt	591.5
Formula	C23H26IN7O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	702675-74-9
Synonyms	BX795
SMILES	C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I