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PDK1 抑制剂

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产品目录号: A11149


产品名 目录号 价格 数量
BX-912 5mg A11149-5
¥ 900.00
BX-912 10mg A11149-10
¥ 1,600.00
BX-912 50mg A11149-50
¥ 5,200.00
BX-912 100mg A11149-100
¥ 7,800.00
BX-912 10mM * 1mL in DMSO A11149-10mM-D
¥ 1,440.00



BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A11149
Mechanism of action Inhibitor
分子量 471.4
化学分子式 C20H23BrN8O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 702674-56-4
Synonyms BX912
化学名称 Pyrrolidine-1-carboxylic acid (3-{5-bromo-4-[2-(1H-imidazol-4-yl)-ethylamino]-pyrimidin-2-ylamino}-phenyl)-amide


BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).
Target Value
PDK-1IC50: 12nM
PKAIC50: 110nM
KDRIC50: 410nM
CDK2/CyclinEIC50: 650nM
Chk1IC50: 830nM
c-KitIC50: 850nM
PKCIC50: 1.25μM
T-FynIC50: 2.1μM
Insulin ReceptorIC50: 6.1μM
GSK-3βIC50: 7.4μM
EGFRIC50: >10μM


Solubility (25°C) * In vitro DMSO 94 mg/mL (199.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol 94 mg/mL (199.42 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.07 mL 212.13mL
0.5 mM 4.24 mL 21.21 mL 42.43 mL
1 mM 2.12 mL 10.61 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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