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BYL719 (Alpelisib)

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PI3K 抑制剂

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产品目录号: A11328

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BYL719 5mg A11328-5
¥ 600.00
BYL719 10mg A11328-10
¥ 900.00
BYL719 25mg A11328-25
¥ 1,200.00
BYL719 50mg A11328-50
¥ 1,400.00
BYL719 10mM * 1mL in DMSO A11328-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.

BYL719 (Alpelisib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 BYL719 (Alpelisib) 发表的文献 (2)
  • J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
  • Pridham KJ, .et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Chemical Information

目录号 A11328
Mechanism of action Inhibitor
分子量 441.5
化学分子式 C19H22F3N5O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1217486-61-7
Synonyms BYL-719
SMILES code CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
化学名称 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide

生物活性

Description
BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
Targets
PI3Kα (Cell-free assay)
5 nM

溶解性

Solubility (25°C) * In vitro DMSO 88 mg/mL (199.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (4.53 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.65 mL 113.25 mL 226.5mL
0.5 mM 4.53 mL 22.65 mL 45.3 mL
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL

*The above data is based on the productmolecular weight 441.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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