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p300/CBP 抑制剂

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产品目录号: A12815


产品名 目录号 价格 数量
C646 10mg A12815-10
¥ 800.00
C646 25mg A12815-25
¥ 1,600.00
C646 50mg A12815-50
¥ 2,800.00
C646 100mg A12815-100
¥ 5,000.00
C646 10mM * 1mL in DMSO A12815-10mM-D
¥ 950.00



C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 C646 发表的文献 (1)
  • Zhifeng Zhang, .et al. XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers, PLoS One, 2017, 12(10): e0186900 PMID: 29049411

Chemical Information

目录号 A12815
Mechanism of action Inhibitor
分子量 445.42
化学分子式 C24H19N3O6
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 328968-36-1
Synonyms C 646, C-646
SMILES code CC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C
化学名称 4-[4-[[5-(4,5-Dimethyl-2-nitropheny?l)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo?-1H-pyrazol-1-yl]benzoic acid


C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
p300/CBP (Cell-free assay)
400 nM(Ki)


Solubility (25°C) * In vitro DMSO 13 mg/mL (29.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.45 mL 112.25 mL 224.51mL
0.5 mM 4.49 mL 22.45 mL 44.9 mL
1 mM 2.25 mL 11.23 mL 22.45 mL
5 mM 0.45 mL 2.25 mL 4.49 mL

*The above data is based on the productmolecular weight 445.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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