CA-4948
目录号: A17005
IRAK4 抑制剂
CA-4948 是一种强效的、口服活性的白细胞介素-1受体相关激酶4（IRAK4）抑制剂。在测试的五种 ABC-DLBCL PDX 模型中，CA-4948 在四种模型中显示出最佳疗效，相比之下，在 GBC-DLBCL 和 ABC/GCB DLBCL PDX 模型中的疗效较低。
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生物活性
| Discription | CA-4948 is a potent, and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. CA-4948 exhibited the greatest efficacy in four of the five ABC-DLBCL PDX models tested as compared to GBC-DLBCL and ABC/GCB DLBCL PDX models. | ||
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产品信息
| 目录号 | A17005 |
|---|---|
| 分子式 | C21H19N7O3 |
| 分子量 | 417.43 |
| CAS号 | 1801343-74-7 |
| SMILES | O=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3 |
| 其他名称 | CA 4948, CA4948 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 27 mg/mL (64.68 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.96 mL | 119.78 mL | 239.56 mL |
| 0.5 mM | 4.79 mL | 23.96 mL | 47.91 mL |
| 1 mM | 2.4 mL | 11.98 mL | 23.96 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.79 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1801343-74-7 | 1801343-74-7 供应商 | 1801343-74-7 花费 | 1801343-74-7 生产商 | 订购 1801343-74-7 | 1801343-74-7 代理商