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Cabozantinib S-malate

Cabozantinib S-malate

Name: Cabozantinib S-malate
SKU: A11349

目录号: A11349

multiple receptor tyrosine kinases inhibitor

Product Citations (2)

Cabozantinib S-malate Chemical Structure

CAS NO. 1140909-48-3

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

库存：现货

规格	价格	数量
50 mg	￥ 990.00
100 mg	￥ 1,710.00
500 mg	￥ 5,060.00

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生物活性

溶解度 *

In vitro (25°C)	DMSO	91 mg/mL (143.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.73 mL	78.67 mL	157.33 mL
0.5 mM	3.15 mL	15.73 mL	31.47 mL
1 mM	1.57 mL	7.87 mL	15.73 mL
5 mM	0.31 mL	1.57 mL	3.15 mL

*The above data is based on the productmolecular weight 635.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11349
作用机制	Inhibitor (抑制剂)
M. Wt	635.59
Formula	C32H30FN3O10
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1140909-48-3
Synonyms	XL184 S-malate; BMS-907351 S-malate
SMILES	O=C([C@H](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O