CAL-101 (GS-1101, Idelalisib)

目录号: A10172

PI3K 抑制剂

CAL-101 (GS-1101, Idelalisib)

CAL-101 (GS-1101, Idelalisib) Chemical Structure

CAS NO. 870281-82-6

CAL-101 (GS-1101,Idelalisib)是PI3K的同种型选择性抑制剂,可诱导慢性淋巴细胞性白血病(CLL)细胞凋亡。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
25 mg
¥ 900.00
50 mg
¥ 1,600.00
100 mg
¥ 3,000.00
10mM * 1mL in DMSO
¥ 760.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

CAL-101 (GS-1101,Idelalisib)是PI3K的同种型选择性抑制剂,可诱导慢性淋巴细胞性白血病(CLL)细胞凋亡。
Targets
Target Value
p110δIC50: 2.5nM
p110γIC50: 89nM
p110βIC50: 565nM
p110αIC50: 820nM
hVps34IC50: 978nM
C2βIC50: >1μM
mTORIC50: >1μM
PIP5KαIC50: >1μM
PIP5KβIC50: >1μM
DNA-PKIC50: 6.729μM
In vitro (25°C) DMSO Warmed: 76 mg/mL (182.94 mM)
Water Insoluble
Ethanol 21 mg/mL (50.55 mM)
In vivo 2% DMSO+20%PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.07 mL 120.37 mL 240.73 mL
0.5 mM 4.81 mL 24.07 mL 48.15 mL
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10172
作用机制 Inhibitor (抑制剂)
M. Wt 415.4
Formula C22H18FN7O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 870281-82-6
Synonyms CAL101
SMILES CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

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