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CAL-101 (GS-1101, Idelalisib)

促销

PI3K 抑制剂

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产品目录号: A10172

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CAL-101 10mg A10172-10
¥ 400.00
CAL-101 25mg A10172-25
¥ 900.00
CAL-101 50mg A10172-50
¥ 1,600.00
CAL-101 100mg A10172-100
¥ 3,000.00
CAL-101 (GS-1101) 10mM * 1mL in DMSO A10172-10mM-D
¥ 760.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.

CAL-101 (GS-1101, Idelalisib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 CAL-101 (GS-1101, Idelalisib) 发表的文献 (3)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168
  • Pridham KJ, .et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
  • Yoshihiro Umezawa, .et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1每induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1), J Biol Chem, 2017, Dec 1; 292(48): 19639每19655 PMID: 28974577

Chemical Information

目录号 A10172
Mechanism of action Inhibitor
分子量 415.4
化学分子式 C22H18FN7O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 870281-82-6
Synonyms CAL101
SMILES code CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
化学名称 (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

生物活性

Description
CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.
Targets
Target Value
p110δIC50: 2.5nM
p110γIC50: 89nM
p110βIC50: 565nM
p110αIC50: 820nM
hVps34IC50: 978nM
C2βIC50: >1μM
mTORIC50: >1μM
PIP5KαIC50: >1μM
PIP5KβIC50: >1μM
DNA-PKIC50: 6.729μM

溶解性

Solubility (25°C) * In vitro DMSO 83 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 35 mg/mL (84.25 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.07 mL 120.37 mL 240.73mL
0.5 mM 4.81 mL 24.07 mL 48.15 mL
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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