CC-223
目录号: A13078
mTOR 抑制剂
CC-223 是一种强效的 mTOR 激酶抑制剂(IC50=16 nM),对相关的脂质激酶 PI3K-alpha 的敏感性超过150倍(IC50=4μM)。
| Discription | CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3K-alpha (IC50=4uM). | |||||
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| 目录号 | A13078 |
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| 分子式 | C21H27N5O3 |
| 分子量 | 397.47 |
| CAS号 | 1228013-30-6 |
| SMILES | CC(C)(C1=NC=C(C=C1)C2=CN=C3C(=N2)N(C(=O)CN3)C4CCC(CC4)OC)O |
| 其他名称 | CC 223, CC223 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 70 mg/mL (176.11 mM) | |
| Water | Insoluble | ||
| Ethanol | 70 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.16 mL | 125.8 mL | 251.59 mL |
| 0.5 mM | 5.03 mL | 25.16 mL | 50.32 mL |
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2