CCT245737

目录号: A17239

CHK1 inhibitor

CCT245737

CCT245737 Chemical Structure

CAS NO. 1489389-18-5

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.

库存: 现货

规格 价格 数量
5 mg
¥ 630.00
10 mg
¥ 980.00
50 mg
¥ 3,150.00
100 mg
¥ 4,900.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.
In vitro DMSO Warmed: 72 mg/mL (189.8 mM)
Water Insoluble
Ethanol Warmed: 9 mg/mL (23.72 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.36 mL 131.81 mL 263.61 mL
0.5 mM 5.27 mL 26.36 mL 52.72 mL
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.3472. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A17239
作用机制 Inhibitor (抑制剂)
M. Wt 379.3472
Formula C16H16F3N7O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1489389-18-5
Synonyms CCT 245737; CCT-245737
SMILES N#CC1=NC=C(NC2=NC=C(C(F)(F)F)C(NC[C@H]3CNCCO3)=C2)N=C1

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