Cediranib (AZD2171) Chemical Structure

CAS NO. 288383-20-0

Cediranib (AZD2171) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 750.00
50 mg
¥ 2,000.00
100 mg
¥ 2,800.00
10mM * 1mL in DMSO
¥ 950.00
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Cediranib (AZD2171) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.
Targets
Target Value
VEGFR2/KDRIC50: 0.5nM
c-KitIC50: 2nM
VEGFR3/FLT4IC50: <=3nM
VEGFR1/FLT1IC50: 5nM
PDGFRβIC50: 5nM
FGFR1IC50: 26nM
PDGFRαIC50: 36nM
CSF-1RIC50: 110nM
SrcIC50: 130nM
AblIC50: 260nM
FLT3IC50: >1μM
HER2/ErbB2IC50: >1μM
CDK2IC50: >1μM
CDK4IC50: >1μM
EGFRIC50: 1.6μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
MEKIC50: >10μM
In vitro (25°C) DMSO 90 mg/mL (199.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.2 mL 110.99 mL 221.98 mL
0.5 mM 4.44 mL 22.2 mL 44.4 mL
1 mM 2.22 mL 11.1 mL 22.2 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10185
MECHANISM OF ACTION Inhibitor
M. Wt 450.5
Formula C25H27FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 288383-20-0
Synonyms Recentin
SMILES CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCC5

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