Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

CEP-32496

促销

Raf 抑制剂

0 Customer Reviews
产品目录号: A13772

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CEP-32496 5mg A13772-5
¥ 1,500.00
CEP-32496 10mg A13772-10
¥ 2,500.00
CEP-32496 25mg A13772-25
¥ 4,900.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity.

CEP-32496

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A13772
Mechanism of action Inhibitor
分子量 553.92
化学分子式 C24H23ClF3N5O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1188910-76-0
Synonyms CEP32496, CEP 32496, AC013773, AC 013773, AC-013773
SMILES code CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
化学名称 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride.

生物活性

Description
CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity.
Targets
Target Value
c-KitKd2nM
LCKKd2nM
PDGFRβKd2nM
RETKd2nM
Abl1Kd3nM
VEGFR2Kd8nM
CSF-1RKd9nM
B-Raf(V600E)Kd14nM
EphA2Kd14nM
EGFRKd22nM
B-RafKd36nM
C-RafKd39nM
c-MetKd513nM
JAK2Kd4.7μM
MEK1Kd7.1μM
MEK2Kd8.3μM
JAK1Kd>10μM
JAK3Kd>10μM
ALKKd>10μM
AuroraAKd>10μM
AuroraBKd>10μM
ERK1Kd>10μM
ERK2Kd>10μM
IGF-1RKd>10μM
INSRKd>10μM
PIK3-CAKd>10μM
PIK3-CBKd>10μM
PLK1Kd>10μM

溶解性

Solubility (25°C) * In vitro DMSO 9 mg/mL (17.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.05 mL 90.27 mL 180.53mL
0.5 mM 3.61 mL 18.05 mL 36.11 mL
1 mM 1.81 mL 9.03 mL 18.05 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。


Keywords:购买 CEP-32496 | CEP-32496 供应商 | 订购 CEP-32496 | CEP-32496 价格 | CEP-32496 生产商 | 订单 CEP-32496 | CEP-32496 代理商 | 购买 1188910-76-0| 1188910-76-0 供应商 | 订购 1188910-76-0 | 1188910-76-0 价格 | 1188910-76-0 生产商 | 订单 1188910-76-0 | 1188910-76-0 代理商|buy CEP-32496 | CEP-32496 Supplier | purchase CEP-32496 | CEP-32496 cost | CEP-32496 manufacturer | order CEP-32496 | CEP-32496 distributor | buy 1188910-76-0| 1188910-76-0 Supplier | purchase 1188910-76-0 | 1188910-76-0 cost | 1188910-76-0 manufacturer | order 1188910-76-0 | 1188910-76-0 distributor