Cephalothin is a semi-synthetic cephalosporin antibiotic classified as a β-lactam antibiotic. It exerts its antibacterial activity by inhibiting class C β-lactamase AmpC with a Ki of 0.32 µM while also binding to penicillin-binding proteins, thereby disrupting the cross-linking of peptidoglycan in the bacterial cell wall. This mechanism impedes bacterial cell wall synthesis, allowing it to effectively target a broad spectrum of bacteria. Cephalothin is applicable in studies related to hematology and nephrotoxicity.
Cephalothin is a semi-synthetic cephalosporin antibiotic classified as a β-lactam antibiotic. It exerts its antibacterial activity by inhibiting class C β-lactamase AmpC with a Ki of 0.32 µM while also binding to penicillin-binding proteins, thereby disrupting the cross-linking of peptidoglycan in the bacterial cell wall. This mechanism impedes bacterial cell wall synthesis, allowing it to effectively target a broad spectrum of bacteria. Cephalothin is applicable in studies related to hematology and nephrotoxicity.
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