Cerdulatinib

Name: Cerdulatinib
SKU: A14210

目录号: A14210

multi-targeted tyrosine kinase 抑制剂

Cerdulatinib Chemical Structure

CAS NO. 1369761-01-2

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.

库存：现货

规格	价格	数量
10 mg	￥ 900.00
25 mg	￥ 2,000.00
50 mg	￥ 3,500.00
10mM * 1mL in DMSO	￥ 1,020.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.

Targets

Target	Value
TYK2	IC50: 0.5nM
MST1	IC50: 4nM
ARK5	IC50: 4nM
MLK1	IC50: 5nM
Fms	IC50: 5nM
AMPK	IC50: 6nM
JAK2	IC50: 6nM
JAK3	IC50: 8nM
TBK1	IC50: 10nM
MARK1	IC50: 10nM
JAK1	IC50: 12nM
PAR1B-a	IC50: 13nM
TSSK	IC50: 14nM
MST2	IC50: 15nM
GCK	IC50: 18nM
JNK3	IC50: 18nM
RSK2	IC50: 20nM
RSK4	IC50: 28nM
Syk	IC50: 32nM
Chk1	IC50: 42nM
FLT4	IC50: 51nM
FLT3	IC50: 90nM
RET	IC50: 105nM
ITK	IC50: 194nM

溶解度 *

In vitro	DMSO	43 mg/mL heating (89.21 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.75 mL	103.73 mL	207.47 mL
0.5 mM	4.15 mL	20.75 mL	41.49 mL
1 mM	2.07 mL	10.37 mL	20.75 mL
5 mM	0.41 mL	2.07 mL	4.15 mL

*The above data is based on the productmolecular weight 482. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14210
MECHANISM OF ACTION	Inhibitor
M. Wt	482
Formula	C20H28ClN7O3S
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1369761-01-2
Synonyms	PRT062070, PRT2070, PRT-2070
SMILES	CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N.Cl