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multi-targeted tyrosine kinase 抑制剂

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产品目录号: A14210


产品名 目录号 价格 数量
Cerdulatinib 10mg A14210-10
¥ 900.00
Cerdulatinib 25mg A14210-25
¥ 2,000.00
Cerdulatinib 50mg A14210-50
¥ 3,500.00
Cerdulatinib 10mM * 1mL in DMSO A14210-10mM-D
¥ 1,020.00



Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.





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Chemical Information

目录号 A14210
Mechanism of action Inhibitor
分子量 482
化学分子式 C20H28ClN7O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1369761-01-2
Synonyms PRT062070, PRT2070, PRT-2070
SMILES code CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N.Cl
化学名称 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide,hydrochloride (1:1)


Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively.
Target Value
TYK2IC50: 0.5nM
MST1IC50: 4nM
ARK5IC50: 4nM
MLK1IC50: 5nM
FmsIC50: 5nM
JAK2IC50: 6nM
JAK3IC50: 8nM
TBK1IC50: 10nM
MARK1IC50: 10nM
JAK1IC50: 12nM
PAR1B-aIC50: 13nM
TSSKIC50: 14nM
MST2IC50: 15nM
GCKIC50: 18nM
JNK3IC50: 18nM
RSK2IC50: 20nM
RSK4IC50: 28nM
SykIC50: 32nM
Chk1IC50: 42nM
FLT4IC50: 51nM
FLT3IC50: 90nM
RETIC50: 105nM
ITKIC50: 194nM


Solubility (25°C)* In vitro DMSO 43 mg/mL heating (89.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.75 mL 103.73 mL 207.47mL
0.5 mM 4.15 mL 20.75 mL 41.49 mL
1 mM 2.07 mL 10.37 mL 20.75 mL
5 mM 0.41 mL 2.07 mL 4.15 mL

*The above data is based on the productmolecular weight 482. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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