Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

目录号: A10194

Topoisomerase inhibitor

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) Chemical Structure

CAS NO. 23541-50-6

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

库存: 现货

规格 价格 数量
10 mg
¥ 600.00
25 mg
¥ 1,000.00
50 mg
¥ 1,600.00
100 mg
¥ 2,600.00
10mM * 1mL in DMSO
¥ 930.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Targets
DNA synthesis (Cell-free assay)
20 nM(Ki)
In vitro (25°C) DMSO 113 mg/mL (200.36 mM)
Water 113 mg/mL (200.36 mM)
Ethanol 13 mg/mL (23.05 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.73 mL 88.65 mL 177.3 mL
0.5 mM 3.55 mL 17.73 mL 35.46 mL
1 mM 1.77 mL 8.87 mL 17.73 mL
5 mM 0.35 mL 1.77 mL 3.55 mL

*The above data is based on the productmolecular weight 564.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10194
MECHANISM OF ACTION Inhibitor
M. Wt 564.0
Formula C27H29NO10.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 23541-50-6
Synonyms Daunorubicin HCl, Rubidomycin HCl
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl

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