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CH5132799

促销

PI3K 抑制剂

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产品目录号: A11169

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CH5132799 5mg A11169-5
¥ 1,800.00
CH5132799 10mg A11169-10
¥ 2,800.00
CH5132799 50mg A11169-50
¥ 7,800.00
CH5132799 100mg A11169-100
¥ 11,000.00
CH5132799 10mM * 1mL in DMSO A11169-10mM-D
¥ 1,950.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM).

CH5132799

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Chemical Information

目录号 A11169
Mechanism of action Inhibitor
分子量 377.42
化学分子式 C15H19N7O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1007207-67-1
Synonyms CH-5132799
SMILES code CS(=O)(=O)N1CCC2=C(N=C(N=C21)N3CCOCC3)C4=CN=C(N=C4)N
化学名称 5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine

生物活性

Description

CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3Kα (IC(50)=0.014 μM).

Targets
Target Value
PI3KαIC50: 14nM
PI3KγIC50: 36nM
PI3KβIC50: 0.12μM
PI3KδIC50: 0.50μM
mTORIC50: 1.6μM
C2βIC50: 5.3μM
C2αIC50: >10μM
Vps34IC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 12 mg/mL (31.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.48 mL 264.96mL
0.5 mM 5.3 mL 26.5 mL 52.99 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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