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Chaetocin

SUV39H HMT 抑制剂

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产品目录号: A12812

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Chaetocin 1mg A12812-1
¥ 850.00
Chaetocin 2mg A12812-2
¥ 1,500.00
Chaetocin 5mg A12812-5
¥ 3,000.00
Chaetocin 10mg A12812-10
¥ 5,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Chaetocin is a histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.

Chaetocin

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Chemical Information

目录号 A12812
Mechanism of action Inhibitor
分子量 696.84
化学分子式 C30H28N6O6S4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 28097-03-2
Synonyms N/A
SMILES code CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
化学名称 (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)?-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl?)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio?-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4?,4'-tetrone

生物活性

Description
Chaetocin is a histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.
Targets
dSU(VAR)3-9 mouse G9a Neurospora crassa DIM5
0.8 μM2.5 μM3 μM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.35 mL 71.75 mL 143.5mL
0.5 mM 2.87 mL 14.35 mL 28.7 mL
1 mM 1.44 mL 7.18 mL 14.35 mL
5 mM 0.29 mL 1.44 mL 2.87 mL

*The above data is based on the productmolecular weight 696.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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