Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

CHIR-124

促销

CHK 抑制剂

0 Customer Reviews
产品目录号: A11046

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CHIR-124 5mg A11046-5
¥ 700.00
CHIR-124 10mg A11046-10
¥ 1,200.00
CHIR-124 25mg A11046-25
¥ 2,200.00
CHIR-124 100mg A11046-100
¥ 6,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).

CHIR-124

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A11046
Mechanism of action Inhibitor
分子量 419.9
化学分子式 C23H22ClN5O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 405168-58-3
Synonyms CHIR124
SMILES code C1CN2CCC1[C@@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl
化学名称 (S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one

生物活性

Description
CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively).
Targets
Target Value
Chk1IC50: 0.3nM
FLT3IC50: 5.8nM
PDGFRIC50: 6.6nM
GSK-3IC50: 23.3nM
FynIC50: 98.8nM
PKAIC50: 103.1nM
PKCγIC50: 110nM
LCKIC50: 158.3nM
CDK2/CyclinAIC50: 191.1nM
VEGFR1/FLT1IC50: 463.6nM
Cdc2/CyclinBIC50: 505.7nM
VEGFR2/Flk1IC50: 577.9nM
PKCβ2IC50: 580nM
PKCαIC50: 580nM
Chk2IC50: 697.4nM
FGFR3IC50: 1.29μM
bFGFRIC50: 2.04μM
CDK4/CyclinDIC50: 2.05μM
PKAβ1IC50: 2.25μM
c-MetIC50: >3μM
ERK2IC50: 4.31μM
CABLIC50: 14.88μM

溶解性

Solubility (25°C) * In vitro DMSO 7 mg/mL (16.67 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.82 mL 119.08 mL 238.15mL
0.5 mM 4.76 mL 23.82 mL 47.63 mL
1 mM 2.38 mL 11.91 mL 23.82 mL
5 mM 0.48 mL 2.38 mL 4.76 mL

*The above data is based on the productmolecular weight 419.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 CHIR-124 | CHIR-124 供应商 | 订购 CHIR-124 | CHIR-124 价格 | CHIR-124 生产商 | 订单 CHIR-124 | CHIR-124 代理商 | 购买 405168-58-3| 405168-58-3 供应商 | 订购 405168-58-3 | 405168-58-3 价格 | 405168-58-3 生产商 | 订单 405168-58-3 | 405168-58-3 代理商|buy CHIR-124 | CHIR-124 Supplier | purchase CHIR-124 | CHIR-124 cost | CHIR-124 manufacturer | order CHIR-124 | CHIR-124 distributor | buy 405168-58-3| 405168-58-3 Supplier | purchase 405168-58-3 | 405168-58-3 cost | 405168-58-3 manufacturer | order 405168-58-3 | 405168-58-3 distributor