CHIR-124
目录号: A11046
CHK 抑制剂
CHIR-124 是一种新型且强效的 Chk1 抑制剂（IC50：Chk1 为 0.32 nM，Chk2 为 697 nM）。
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生物活性
| Discription | CHIR-124 is a novel and potent Chk1 inhibitor (IC50: 0.32 nM and 697 nM for Chk1 and Chk2 respectively). | ||
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产品信息
| 目录号 | A11046 |
|---|---|
| 分子式 | C23H22ClN5O |
| 分子量 | 419.9 |
| CAS号 | 405168-58-3 |
| SMILES | C1CN2CCC1[C@@H](C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl |
| 其他名称 | CHIR124 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 6 mg/mL (14.29 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.82 mL | 119.08 mL | 238.15 mL |
| 0.5 mM | 4.76 mL | 23.82 mL | 47.63 mL |
| 1 mM | 2.38 mL | 11.91 mL | 23.82 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 405168-58-3 | 405168-58-3 供应商 | 405168-58-3 花费 | 405168-58-3 生产商 | 订购 405168-58-3 | 405168-58-3 代理商