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CHIR-98014

促销

GSK-3 抑制剂

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产品目录号: A11085

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CHIR-98014 5mg A11085-5
¥ 1,100.00
CHIR-98014 10mg A11085-10
¥ 2,000.00
CHIR-98014 50mg A11085-50
¥ 6,000.00
CHIR-98014 100mg A11085-100
¥ 10,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.

CHIR-98014

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Chemical Information

目录号 A11085
Mechanism of action Inhibitor
分子量 486.3
化学分子式 C20H17Cl2N9O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 252935-94-7
Synonyms CHIR98014
SMILES code C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N
化学名称 2,6-Pyridinediamine, N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-

生物活性

Description
CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.
Targets
Target Value
GSK-3βIC50: 0.58nM
GSK-3αIC50: 0.65nM
p70S6KIC50: >1μM
c-SrcIC50: >1μM
bFGFRIC50: >1μM
KDRIC50: >2μM
IGF-1RIC50: >2μM
Insulin ReceptorIC50: >2μM
Cdc2IC50: 3.7μM
Akt1IC50: >5μM
Tie-2IC50: >5μM
FLT1IC50: >5μM
CK1εIC50: >5μM
ERK2IC50: >10μM
PKCαIC50: >10μM
p90RSK2IC50: >10μM
Chk1IC50: >10μM
DNA-PKIC50: >10μM
PI3KIC50: >10μM

溶解性

Solubility (25°C)* In vitro DMSO 8 mg/mL heating (16.45 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.56 mL 102.82 mL 205.63mL
0.5 mM 4.11 mL 20.56 mL 41.13 mL
1 mM 2.06 mL 10.28 mL 20.56 mL
5 mM 0.41 mL 2.06 mL 4.11 mL

*The above data is based on the productmolecular weight 486.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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