CHIR-99021

目录号: A10199

GSK-3 Inhibitor

CHIR-99021 Chemical Structure

CAS NO. 252917-06-9

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.

库存: 现货

规格 价格 数量
2 mg
¥ 450.00
5 mg
¥ 700.00
25 mg
¥ 1,800.00
100 mg
¥ 4,700.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
Targets
GSK-3β GSK-3α
6.7 nM10 nM
In vitro DMSO 78 mg/mL warmed (167.61 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.49 mL 107.46 mL 214.92 mL
0.5 mM 4.3 mL 21.49 mL 42.98 mL
1 mM 2.15 mL 10.75 mL 21.49 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10199
MECHANISM OF ACTION Inhibitor
M. Wt 465.3
Formula C22H18Cl2N8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 252917-06-9
Synonyms GSK-3 Inhibitor XVI, CT 99021, CHIR99021
SMILES CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

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