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Chlormezanone (Trancopal)是一种非苯二氮卓类药物，用于治疗焦虑症。已经建议将其用于治疗肌肉痉挛。氯甲酮与中央苯并二氮杂receptor受体结合，后者与GABA受体发生变构作用。这增强了抑制性神经递质GABA的作用，增强了对网状激活系统的抑制作用，并阻断了在刺激网状通路后发生的皮质和边缘觉醒。
靶点信息
| In vitro | DMSO | 51 mg/mL (186.31 mM) | |
| Water | Insoluble | ||
| Ethanol | 24 mg/mL (87.67 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.54 mL | 182.68 mL | 365.36 mL |
| 0.5 mM | 7.31 mL | 36.54 mL | 73.07 mL |
| 1 mM | 3.65 mL | 18.27 mL | 36.54 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.31 mL |
*The above data is based on the productmolecular weight 273.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10201 |
|---|---|
| M. Wt | 273.7 |
| Formula | C11H12ClNO3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 80-77-3 |
| Synonyms | Trancopal |
| SMILES | CN1C(S(=O)(=O)CCC1=O)C2=CC=C(C=C2)Cl |
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