Signaling Pathway
| Discription | Chlorthalidone is a diuretic drug used to treat hypertension. It is described as a thiazide diuretic. Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. Chlortalidone is often used in the management of hypertension and edema. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion resulting in the excretion of water. |
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| 目录号 | A17253 |
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| 分子式 | C14H11ClN2O4S |
| 分子量 | 338.76 |
| CAS号 | 77-36-1 |
| SMILES | C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O |
| 其他名称 | Chlorthalidone; Chlortalidone; Phthalamudine; Hygroton; Chlorphthalidolone; Phthalamodine; Oxodoline; Phthalamudine; Thalitone; |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 58 mg/mL (171.2 mM) | |
| Water | Insoluble | ||
| Ethanol | 26 mg/mL (76.74 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.52 mL | 147.6 mL | 295.19 mL |
| 0.5 mM | 5.9 mL | 29.52 mL | 59.04 mL |
| 1 mM | 2.95 mL | 14.76 mL | 29.52 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.9 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
