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CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor with the IC50s of 7.9 nM and 27.9 nM, respectively. CHMFL-ABL-039 is used in the research of chronic myeloid leukemia.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.82 mL | 84.09 mL | 168.17 mL |
| 0.5 mM | 3.36 mL | 16.82 mL | 33.63 mL |
| 1 mM | 1.68 mL | 8.41 mL | 16.82 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.36 mL |
*The above data is based on the productmolecular weight 594.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13182 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 594.63 |
| Formula | C31H33F3N6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2304344-56-5 |
| SMILES | O=C(NC1=CN=C(NC(C2CC2)=O)C=C1)CC3=CC=C(NC(C4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4)=O)C=C3 |
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