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CHS-828 is a potent inhibitor of NAD+ biosynthesis enzyme NAMPT with IC50 <25 nM.
靶点信息
| NAMPT | NAMPT | |||
| 25 nM | 120 nM(Kd) |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.89 mL | 134.46 mL | 268.92 mL |
| 0.5 mM | 5.38 mL | 26.89 mL | 53.78 mL |
| 1 mM | 2.69 mL | 13.45 mL | 26.89 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
*The above data is based on the productmolecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12515 |
|---|---|
| MECHANISM OF ACTION | Inhibitor |
| M. Wt | 371.86 |
| Formula | C19H22ClN5O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 200484-11-3 |
| Synonyms | GMX1778, GMX-1778, GMX 1778, CHS828, CHS 828 |
| SMILES | ClC1=CC=C(OCCCCCC/N=C(\N=C2C=CNC=C/2)NC#N)C=C1 |
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