CIL56
CIL56（又名 CA3）是一种YAP1/TEAD转录活性强效抑制剂，具有高度选择性地靶向YAP1高表达的、具有癌症干细胞（CSC）特征的耐药性食管腺癌细胞的能力。该化合物通过铁依赖性活性氧（ROS）生成诱导铁死亡（ferroptosis），为克服侵袭性肿瘤的治疗耐药性提供了一种全新的治疗策略。
顾客使用 Adooq 产品发表的高质量科研文献
Adooq用户使用CIL56发表的1篇文献
生物活性
| Discription | CIL56 (CA3) is a potent inhibitor of YAP1/TEAD transcriptional activity, selectively targeting YAP1-high, therapy-resistant esophageal adenocarcinoma cells with cancer stem cell (CSC) characteristics. It induces ferroptosis through iron-dependent reactive oxygen species (ROS) generation, offering a novel approach for overcoming resistance in aggressive tumors. | |||||
|---|---|---|---|---|---|---|
| Cell Research |
|
产品信息
| 目录号 | A17141 |
|---|---|
| 分子式 | C23H27N3O5S2 |
| 分子量 | 489.6 |
| CAS号 | 300802-28-2 |
| SMILES | O=S(C1=CC2=C(C=C1)C3=C(C=C(S(=O)(N4CCCCC4)=O)C=C3)/C2=N\O)(N5CCCCC5)=O |
| 其他名称 | CIL 56, CIL-56 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 86 mg/mL (175.64 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.42 mL | 102.12 mL | 204.25 mL |
| 0.5 mM | 4.08 mL | 20.42 mL | 40.85 mL |
| 1 mM | 2.04 mL | 10.21 mL | 20.42 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
Keywords: 购买 CIL56 | CIL56 供应商 | CIL56 花费 | CIL56 生产商 | 订购 CIL56 | CIL56 代理商
| 购买 300802-28-2 | 300802-28-2 供应商 | 300802-28-2 花费 | 300802-28-2 生产商 | 订购 300802-28-2 | 300802-28-2 代理商