Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

Cilengitide

促销

0 Customer Reviews
产品目录号: A12372

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Cilengitide 5mg A12372-5
¥ 1,200.00
Cilengitide 10mg A12372-10
¥ 1,800.00
Cilengitide 25mg A12372-25
¥ 3,200.00
Cilengitide 50mg A12372-50
¥ 5,500.00
Cilengitide 10mM * 1mL in DMSO A12372-10mM-D
¥ 2,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.

Cilengitide

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Cilengitide 发表的文献 (5)
  • Rosalie Richards, .et al. 4D imaging and analysis of multicellular tumour spheroid cell migration and invasion, bioRxiv, 2018, 15 Oct 2018
  • Hiroki Kanazawa, .et al. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts, PLoS One, 2017, 12(2): e0173051 PMID: 28235037
  • Yasuda J, .et al. T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway, Naunyn Schmiedebergs Arch Pharmacol, 2017, Nov;390(11):1135-1144 PMID: 28785775
  • Yasuda J, .et al. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts, Eur J Pharmacol, 2017, Jul 15;807:64-70 PMID: 28457922
  • Hsian-Yu Wang, .et al. Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses, Onco Targets Ther, 2016, 9: 2961每2973 PMID: 27284246

Chemical Information

目录号 A12372
Mechanism of action N/A
分子量 588.66
化学分子式 C27H40N8O7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 188968-51-6
Synonyms EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497
SMILES code CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N
化学名称 2-((2S,5R,8S,11S)-5-benzyl-11-(3-((diaminomethylene)amino)propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid

生物活性

Description
Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (169.87 mM)
Water 8 mg/mL (13.59 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.99 mL 84.94 mL 169.88mL
0.5 mM 3.4 mL 16.99 mL 33.98 mL
1 mM 1.7 mL 8.49 mL 16.99 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 588.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。


Keywords:购买 Cilengitide | Cilengitide 供应商 | 订购 Cilengitide | Cilengitide 价格 | Cilengitide 生产商 | 订单 Cilengitide | Cilengitide 代理商 | 购买 188968-51-6| 188968-51-6 供应商 | 订购 188968-51-6 | 188968-51-6 价格 | 188968-51-6 生产商 | 订单 188968-51-6 | 188968-51-6 代理商|buy Cilengitide | Cilengitide Supplier | purchase Cilengitide | Cilengitide cost | Cilengitide manufacturer | order Cilengitide | Cilengitide distributor | buy 188968-51-6| 188968-51-6 Supplier | purchase 188968-51-6 | 188968-51-6 cost | 188968-51-6 manufacturer | order 188968-51-6 | 188968-51-6 distributor