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cis-Pralsetinib

cis-Pralsetinib

Name: cis-Pralsetinib
SKU: A21586

目录号: A21586

RET inhibitor

cis-Pralsetinib Chemical Structure

CAS NO. 2097132-93-7

cis-Pralsetinib (cis-BLU-667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50s ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types.

库存：现货

规格	价格	数量
5 mg	￥ 1,170.00
10 mg	￥ 2,020.00
50 mg	￥ 5,980.00
100 mg	￥ 11,960.00

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.74 mL	93.7 mL	187.41 mL
0.5 mM	3.75 mL	18.74 mL	37.48 mL
1 mM	1.87 mL	9.37 mL	18.74 mL
5 mM	0.37 mL	1.87 mL	3.75 mL

*The above data is based on the productmolecular weight 533.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21586
作用机制	Inhibitor (抑制剂)
M. Wt	533.6
Formula	C27H32FN9O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2097132-93-7
Synonyms	cis-BLU-667, BLU667, BLU 667
SMILES	O=C([C@@]1(OC)CC[C@@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C