Citatuzumab bogatox (VB6-845) is a recombinant immunotoxin consisting of a humanized antibody Fab fragment targeting epithelial cell adhesion molecule (EpCAM) linked to a modified cytotoxin, bouganin. This agent binds selectively to EpCAM-positive cell lines, inducing apoptosis effectively. Citatuzumab bogatox demonstrates robust activity in EpCAM-positive human tumor xenograft models, highlighting its potential for targeted cancer therapy applications.
Citatuzumab bogatox (VB6-845) is a recombinant immunotoxin consisting of a humanized antibody Fab fragment targeting epithelial cell adhesion molecule (EpCAM) linked to a modified cytotoxin, bouganin. This agent binds selectively to EpCAM-positive cell lines, inducing apoptosis effectively. Citatuzumab bogatox demonstrates robust activity in EpCAM-positive human tumor xenograft models, highlighting its potential for targeted cancer therapy applications.
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