CK-1827452 (Omecamtiv mecarbil)

Name: CK-1827452 (Omecamtiv mecarbil)
SKU: A11206
Price: 175 CNY
Rating: 5 (11 reviews)

目录号: A11206

Myosin activator

11 篇发表文献

CK-1827452 是一种选择性的心脏特异性肌球蛋白激活剂。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥490.00	现货
10mg	¥840.00	现货
25mg	¥1,400.00	现货
50mg	¥2,520.00	现货
100mg	¥3,780.00	现货
*10mM 1mL in DMSO**	¥420.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用CK-1827452 (Omecamtiv mecarbil)发表的11篇文献

Oleg Lookin, .et al. , Clin Exp Pharmacol Physiol, 2021, Aug 29 PMID: 34459025

Gabor A. Fulop, .et al. , Basic Res Cardiol, 2021, 116(1): 24 PMID: 33844095

Wanjian Tang, .et al. , J Biol Chem, 2019, October 2 PMID: 31578282

Thinh T. Kieu, .et al. , Biophysical Journal, 2019, 2019 PMID: 31103235

Alexandre J. S. Ribeiro, .et al. , Circ Res, 2017, May 12; 120(10): 1572-1583 PMID: 28400398

Anja M. Swenson, .et al. , J Biol Chem, 2017, Mar 3; 292(9): 3768-3778 PMID: 28082673

Nánási P Jr, .et al. , Eur J Pharmacol, 2017, Aug 15;809:73-79 PMID: 28506910

Horváth B, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2017, Dec;390(12):1239-1246 PMID: 28940010

Szentandrassy N, .et al. , J Physiol Pharmacol, 2016, Aug;67(4):483-489 PMID: 27779469

L Nagy, .et al. , Br J Pharmacol, 2015, Sep; 172(18): 4506-4518 PMID: 26140433

Larissa Butler, .et al. , Toxicol Sci, 2015, Jun;145(2):396-406 PMID: 25820236

生物活性

Discription

CK-1827452 is a selective cardiac specific myosin activator.

Targets

Target	Value

产品信息

目录号	A11206
分子式	C20H24FN5O3
分子量	401.43
CAS号	873697-71-3
SMILES	CC1=NC=C(C=C1)NC(=O)NC2=CC=CC(=C2F)CN3CCN(CC3)C(=O)OC
其他名称	CK1827452, Omecamtiv Mecarbil
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	73 mg/mL (181.84 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (12.45 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.91 mL	124.55 mL	249.11 mL
0.5 mM	4.98 mL	24.91 mL	49.82 mL
1 mM	2.49 mL	12.46 mL	24.91 mL
5 mM	0.5 mL	2.49 mL	4.98 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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