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CL-387785 (EKI-785)

EGFR 抑制剂

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产品目录号: A13146

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CL-387785 10mg A13146-10
¥ 1,200.00
CL-387785 25mg A13146-25
¥ 2,500.00
CL-387785 50mg A13146-50
¥ 4,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.

CL-387785 (EKI-785)

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Chemical Information

目录号 A13146
Mechanism of action Inhibitor
分子量 381.23
化学分子式 C18H13BrN4O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 194423-06-8
Synonyms WAY-EKI 785, CL387785, CL 387785, EKI785, WAY-EKI785, EKI 785, EKI-785
SMILES code CC#C/C(O)=N/C1=CC(C(NC2=CC=CC(Br)=C2)=NC=N3)=C3C=C1
化学名称 (Z)-N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynimidic acid

生物活性

Description
CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.
Targets
EGFR
370 pM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.23 mL 131.15 mL 262.31mL
0.5 mM 5.25 mL 26.23 mL 52.46 mL
1 mM 2.62 mL 13.12 mL 26.23 mL
5 mM 0.52 mL 2.62 mL 5.25 mL

*The above data is based on the productmolecular weight 381.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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