CNX-2006

目录号: A13755

EGFR inhibitor

CNX-2006 Chemical Structure

CAS NO. 1375465-09-0

CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.

库存: 现货

规格 价格 数量
10 mg
¥ 1,800.00
25 mg
¥ 3,500.00
50 mg
¥ 6,000.00
100 mg
¥ 10,000.00
10mM * 1mL in DMSO
¥ 1,570.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.
In vitro DMSO 100 mg/mL (183.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 29 mg/mL (53.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.33 mL 91.65 mL 183.31 mL
0.5 mM 3.67 mL 18.33 mL 36.66 mL
1 mM 1.83 mL 9.17 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL

*The above data is based on the productmolecular weight 545.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13755
MECHANISM OF ACTION Inhibitor
M. Wt 545.53
Formula C26H27F4N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1375465-09-0
Synonyms CNX2006, CNX 2006
SMILES COC1=C(C=CC(=C1)NC2CN(C2)CCF)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F

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