CO-1686 (Rociletinib, AVL-301)

目录号: A13028

EGFR inhibitor

CO-1686 (Rociletinib, AVL-301)

CO-1686 (Rociletinib, AVL-301) Chemical Structure

CAS NO. 1374640-70-6

CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor (EGFR) currently being studied for the treatment of non-small cell lung cancer (NSCLC).

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 800.00
25 mg
¥ 1,300.00
50 mg
¥ 1,600.00
10mM * 1mL in DMSO
¥ 1,480.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor (EGFR) currently being studied for the treatment of non-small cell lung cancer (NSCLC).
In vitro (25°C) DMSO 100 mg/mL (180 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18 mL 90 mL 180 mL
0.5 mM 3.6 mL 18 mL 36 mL
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 555.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A13028
MECHANISM OF ACTION Inhibitor
M. Wt 555.55
Formula C27H28F3N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1374640-70-6
Synonyms CO1686; AVL-301; CNX-419 ;AVL 301; AVL301; CNX419
SMILES CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

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