Cobicistat (GS-9350)

Name: Cobicistat (GS-9350)
SKU: A11277
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A11277

CYP3A 抑制剂

Cobicistat 是一种强效的细胞色素P450 3A酶抑制剂，包括重要的 CYP3A4 亚型。它还抑制肠道转运蛋白，增加了包括阿塔那韦、达芦那韦和 替诺福韦 阿拉酚胺酯在内的几种HIV药物的整体吸收。

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Grouped product items
规格	价格	库存
1mg	¥210.00	现货
2mg	¥315.00	现货
5mg	¥560.00	现货
10mg	¥840.00	现货
25mg	¥1,505.00	现货
50mg	¥2,520.00	现货
100mg	¥3,675.00	现货
*10mM 1mL in DMSO**	¥735.00	现货
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Data Sheet

SDS

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生物活性

Discription

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

Targets

Target	Value

产品信息

目录号	A11277
分子式	C40H53N7O5S2
分子量	766
CAS号	1004316-88-4
SMILES	CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
其他名称	GS9350
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	85 mg/mL (109.53 mM)
	Water	Insoluble
	Ethanol	85 mg/mL (109.53 mM)
In vivo	5% DMSO+40% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.05 mL	65.27 mL	130.55 mL
0.5 mM	2.61 mL	13.05 mL	26.11 mL
1 mM	1.31 mL	6.53 mL	13.05 mL
5 mM	0.26 mL	1.31 mL	2.61 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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