Cobicistat (GS-9350)

目录号: A11277

CYP3A Inhibitor

Cobicistat (GS-9350)

Cobicistat (GS-9350) Chemical Structure

CAS NO. 1004316-88-4

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

库存: 现货

规格 价格 数量
2 mg
¥ 1,000.00
5 mg
¥ 1,600.00
10 mg
¥ 2,100.00
25 mg
¥ 3,800.00
10mM * 1mL in DMSO
¥ 1,800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.
Targets
CYP3A
30 nM-285 nM
In vitro DMSO 100 mg/mL (128.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (128.86 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.05 mL 65.27 mL 130.55 mL
0.5 mM 2.61 mL 13.05 mL 26.11 mL
1 mM 1.31 mL 6.53 mL 13.05 mL
5 mM 0.26 mL 1.31 mL 2.61 mL

*The above data is based on the productmolecular weight 766.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11277
MECHANISM OF ACTION Inhibitor
M. Wt 766.0
Formula C40H53N7O5S2
Solubility DMSO
Purity >99%
Storage at -20°C 3 years Powder
CAS No. 1004316-88-4
Synonyms GS9350
SMILES CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

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