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Combretastatin A4是在体内和体外的抗肿瘤，抗血管生成和抗转移药。Combretastatin A4是一种微管靶向剂，可与β-微管蛋白结合，Kd为0.4μM。
| In vitro (25°C) | DMSO | 58 mg/mL (183.34 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 31 mg/mL (97.99 mM) | ||
| In vivo | 5% DMSO+50% PEG 300+ddH2O | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.61 mL | 158.05 mL | 316.11 mL |
| 0.5 mM | 6.32 mL | 31.61 mL | 63.22 mL |
| 1 mM | 3.16 mL | 15.81 mL | 31.61 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
*The above data is based on the productmolecular weight 316.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12601 |
|---|---|
| M. Wt | 316.35 |
| Formula | C18H20O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 117048-59-6 |
| Synonyms | CRC 87-09, NSC 817373 |
| SMILES | COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)O |
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