Cosibelimab (CK-301; TG-1501) is a fully human monoclonal antibody with high affinity for PD-L1, effectively inhibiting its interaction with PD-1. This antibody features a functional Fc domain, enabling it to induce antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). These mechanisms facilitate the targeted killing of PD-L1-expressing cell lines, including various lymphoma cells, making it a critical tool for research in oncology and immunotherapy.
Cosibelimab (CK-301; TG-1501) is a fully human monoclonal antibody with high affinity for PD-L1, effectively inhibiting its interaction with PD-1. This antibody features a functional Fc domain, enabling it to induce antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). These mechanisms facilitate the targeted killing of PD-L1-expressing cell lines, including various lymphoma cells, making it a critical tool for research in oncology and immunotherapy.
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